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Experimental investigations have reported interactions with VEGFR2 phosphorylation, focal adhesion kinase (FAK) activation, ERK1/2 signaling, nitric oxide-associated pathways, and extracellular matrix regulatory networks

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The mitochondrial-specific antioxidant CoQ10 afforded very minimal neuroprotection from chronic alcohol administration (data not shown), similar to our unpublished data in cell culture studies, which was attributed to the impermeability of exogenous CoQ10 across the cellular and mitochondrial membranes